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Also, a very high incidence of vascular alterations was reported in a case series of 22 patients with bacterial meningitis, with markedly increased systolic peak velocities (> 210 cm/s) in seven patients [ 13].
Also, a correlation between some clinical data and chromosomal alterations was reported, such as association between the gains of 1q and 2q and a refractory clinical response (Bergamo et al, 2000), and more frequent losses at 13q, 8p and 9q in metastatic than in primary tumours (Kujawski et al, 1999).
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In contrast, in an experimental cholangitis study, comparable sublingual and gut alterations were reported [12].
Recently, severe sublingual microcirculatory alterations were reported with high oxygen inspired fraction in healthy volunteers.
Although the underlying mechanism remains poorly understood, inflammation causing cerebral endothelial activation and blood brain barrier (BBB) alterations were reported in several models of septic brain [1, 2].
For BRAF and KRAS, activating mutations at positions known to frequently carry alterations are reported [11], [58].
Tendons of Fbn2-null mice have been previously analyzed and no structural alterations were reported, though the level of collagen cross-linking was reduced [17].
In spite of their key role in DNA repair, polymorphic forms of DNA repair polymerases have been poorly described, except in several studies carried out with Polι and Polβ, where a significant number of genetic alterations were reported [35], [21] [23], [41], [42].
Interestingly, corresponding alterations were reported in psychiatric disorders and CVD.
Such alterations were reported to be partially reversed in HRT-treated postmenopausal women [ 40, 41].
In contrast, in an experimental cholangitis study, comparable sublingual and gut alterations were reported [ 12].
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