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The association of resistance to pentamidine with mitochondrial alterations was based on studies with its fluorescent analogue DB99 in which drug accumulation in the kinetoplast was observed with wild-type L. donovani but not with a resistant strain [ 143].
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These alterations are based on variations in molecular weights and intensities of polypeptides bands as well as gain or loss of protein bands that led to highly levels of protein polymorphism.
These protein alterations are based on changes in bands molecular weights (MWs), bands intensities, fractionation of some bands, appearance of new bands (unique bands), and disappearance of some bands (polymorphic bands) as shown in (Table 3) and.
These alterations are based on variations in number of polypeptide bands, molecular weights, and intensities of polypeptides bands as well as gain or loss of protein bands that led to high levels of protein polymorphisms.
Clinical decisions about dosage alteration were based on this concentration.
All of the alterations were base substitutions, and in all cases the wild-type allele was preserved.
Fourteen of the 27 included studies investigated mechanical, material, as well as morphological properties (i.e., stiffness, Young's modulus, and CSA), which is essential in order to clarify if a change in tendon stiffness was based on alterations of the material properties and/or tendon hypertrophy.
With regard to short application of IA, our grading system was based on the alterations seen in the apical and basal mucosa, such as hyperemia, hemorrhages and necrosis.
The design of our study was based on an alteration of the maternal environment of two inbred strains of mice, C57 and DBA, which were fostered with non-related mother strains.
The Inconel alloy autoclave used for the hydrothermal alteration experiment is based on the study by Seyfried et al. (1979).
Studies of the overall chromosomal alterations in carcinomas are based on loss of heterozygosity (LOH) analyses and comparative genomic hybridisation (CGH).
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