Sentence examples for alterations uncovered from inspiring English sources

Introducing dominant oncogenic alterations uncovered in human myeloid malignancies into the mouse germline provides a powerful approach for studying leukemogenesis.

The pathological alterations uncovered in this work might therefore represent a starting point for the elucidation of the circumstances and the cellular mechanisms responsible for the neurological and behavioral impairments recorded in humans infected with T. gondii.

Subtle analyses on the residue alterations uncovered the effects of five nucleotide mutations on the functions of the RNAP and capsid proteins, which account for the host-bursting efficiency.

With vast numbers of potentially pathogenic genomic alterations being uncovered, experimental systems to test the functional significance of these changes, and to place them in the context of gene networks and biochemical pathways, become even more essential (Lamitina, 2006; Suter et al., 2006; Kabashi et al., 2010; Roy et al., 2010).

We compared the genetic landscape between primary liver and metastatic lung tumor tissues and performed an in-depth investigation of the genetic alterations to uncover potential biomarkers for tumor progression and metastasis.

Analysis of motor abilities in the Mbd5 +/GT mice uncovered alterations in strength, balance, and movement coordination.

Although relatively broad, our screen was not genome-wide and it is foreseeable that other rare RAS-activating alterations could be uncovered.

These subtypes uncovered specific alterations in DNA methylation and transcription as well as in signaling pathways involved in tumor-stromal cross-talk.

For example, mutational analysis of the tyrosine phosphatase (PTP) gene superfamily uncovered genetic alterations in about 26% of colorectal tumors.

Overall, deep-coverage sequence analysis techniques uncovered VHL alterations within the neoplastic fraction of these tumors at higher frequencies than previously reported.

Such plasticity may also allow for cellular alterations that facilitate newly uncovered and important functional characteristics that have been linked to EMT, such as increased tumor-initiation and self-renewal capacity [ 4, 5] and increased resistance to conventional therapies [ 6, 7].