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Optimization procedures are often iterative and provide for shape alterations to increase structural shell features.
The ability of these microglia-induced alterations to increase angiogenesis was also evaluated in a number of in vitro assays.
Those with epigenetic alterations to increase metabolic efficiency and caloric storage would have a survival advantage in an adverse environment.
Following this, a few minor adjustments were made, including the addition of extra background questions and a question for screening respondents trading a very high proportion of their remaining life expectancy, and slight wording alterations to increase clarity.
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Most often, such alterations appear to increase the fitness of the parasites at the expense of that of their hosts, a phenomenon known as "host manipulation".
Similarly, alterations intended to increase the detection rate led to increases in the false positive rate.
The severity of the tau alterations appears to increase inexorably throughout aging (Hebert et al., 2003; Thal et al., 2004).
Its relevance in controlling energy homeostasis is illustrated by the fact that humans with mutations in PPARγ typically develop severe metabolic complications characterized by insulin resistance, diabetes, lipodystrophy, hypertension, and dyslipidaemia; a cluster of metabolic alterations known to increase cardiovascular risk.
Normal dietary alterations to similarly increase large intestinal fermentation would probably arise from larger quantities of less rapidly digested carbohydrates.
Our results suggest that the bone phenotype in dtd mice is a primary bone defect, which is not due to defects in osteoblast mineralization, osteoclast differentiation or systemic alterations, but to increased degradation of the altered organic bone matrix.
The aim of this study is to localize and to specify further DTI abnormalities in schizophrenia by combining DTI with magnetization transfer imaging (MTI), a technique sensitive to myelin and axonal alterations in order to increase specificity of DTI findings.
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