Sentence examples for alterations to correct from inspiring English sources

A promising alternative to gene-addition is in-situ replacement of disease-causing gene mutation by homologous recombination (HR) between the endogenous genomic sequence and an exogenous DNA template harbouring desired sequence alterations to correct the genetic defect.

Preliminary lab work is underway exploring alterations of human cells to correct inherited blindness.

While an acute response is often adaptive and physiological to correct alterations of homeostasis, a chronic disease process is often accompanied by the wrong program [ 70, 73].

As with methods to correct for alteration during Thellier-type methods, this correction should be treated with caution, especially for cases when the ratio of the pre- and post-heating ARMs is far from unity; however, this correction is a standard step in more recent applications of the Shaw (1974) method (e.g., Yamamoto et al. (2003)).

It is generally believed that the tumor formation is the results of the gene alterations and gene therapy aims to correct them.

Objectives: This study investigated the role of the liver in the efficacy of balanced and unbalanced solutions to correct acid base alterations and renal haemodynamics and microvascular oxygenation in a rat model of resuscitated hemorrhagic shock (HS).

This remodelling in males might be a compensatory mechanism but still insufficient to correct CL alterations.

Therefore, therapies aimed to correct these alterations should be taken into account.

After an initial period of 4 to 6 weeks manual medicine methods as well as acupuncture are then used to correct the alterations [7].

In light of the reduced success of previous attempts to correct genetic alterations in pancreatic cancer through gene therapy, these considerations also highlight the possibility that early intervention against stress-induced proteins may be more beneficial for the management of this cancer and likely other malignancies, which are known to associate with Kras mutations.

Surprisingly, SSc endothelial cells over-express pro-angiogenic transcripts, but also show up-regulation of genes exerting a powerful negative control, and down-regulation of genes critical to cell migration and extracellular matrix-cytoskeleton coupling, all alterations that provide an impediment to correct angiogenesis.