The phrase "alterations to both" is correct and usable in written English.
It can be used when discussing changes or modifications that apply to two items or subjects.
Example: "The report includes alterations to both the budget and the timeline for the project."
Alternatives: "changes to both" or "modifications to both".
Analysis of the underlying mechanisms revealed that rapamycin increased longevity specifically through the TORC1 branch of the TOR pathway, through alterations to both autophagy and translation.
(III, B) Correct any lipid profile alterations to both slow down the progress of nephropathy and reduce the associated cardiovascular risk.
Rapamycin-mediated life span extension was not associated with alterations in either IIS or AMP-activated protein kinase (AMPK) activity but was blocked by alterations to both autophagy and translation.
This study directly addresses the effect of addition of a CBM to a CD in terms of changes in enzyme activity on insoluble substrate and on alterations to both the surface and bulk properties of non-crystalline cellulose films.
Taken together, our results indicate that INPP1 ablation may lead to impairments in glycolytic metabolism and lowering of glucose-derived LPA levels that are the result of transcriptional alterations to both glucose transporters and hexokinase.
In summary, this study presents novel evidence that a single dose of zoledronic acid rapidly induces significant alterations to both the cellular component and the extra-cellular matrix of the metaphysis, the area of bone comprising the metastatic niche.
Concurrent alteration to both markers, however, produced a 2.81-fold increase in the risk of recurrence (CI 0.94 8.40).
After adjusting for grade and stage, the risk ratios for recurrence were 0.45 (CI 0.23 0.88) for a single alteration, and 2.21 (CI 0.68 7.19) for alteration to both markers.
The p16/pRb index was the closest to significance in this cohort, being associated with a relative risk of 1.23 (CI 0.27 5.57) for alteration to either marker, and 5.28 (CI 0.88 31.72) for concurrent alteration to both markers.
This was associated with a relative risk of 2.67 (CI 0.59 12.01) for alteration to either p53 or p16, and of 15.27 (CI 1.41 165.59) for concurrent alteration to both markers.
We report in particular that our high throughput methods demonstrate that there is a common gene alteration to both tumors (loss of chromosome 1p), which may represent an early event common in the histogenesis of both tumors.
