Sentence examples for alterations that provide from inspiring English sources

Hot spots for somatic mutations in carcinomas represent protein alterations that provide a selective growth advantage to the cell.

Therefore, protein alterations that provide a selective growth advantage to the cell would have already occurred in cells of LULs-NDE before histologic transformation into dysplastic cells.

In general terms, improvements in enzymatic yields can be understood as cell wall alterations that provide hydrolytic enzymes greater accessibility to the cell wall matrix polysaccharides, and these differences in glucose versus xylose released may be interpreted as differences in how the pretreatments alter the polysaccharide accessibility to enzymes.

Furthermore, hotspot mutations in carcinomas represent protein alterations that provide a selective growth advantage to the cell, and missense mutations at six hotspots account for 25 30% of the mutations (Greenblatt et al, 1994; Hainaut et al, 1997; Hussain and Harris, 1999; Ito et al, 2000).

Genomic alterations that provide the potential for metastatic growth can be characterised as either those that also drive primary tumour growth advantage, those that provide potential for dissemination and infiltration [ 23] or those that enable continued growth within the microenvironment of the new organ [ 24].

Surprisingly, SSc endothelial cells over-express pro-angiogenic transcripts, but also show up-regulation of genes exerting a powerful negative control, and down-regulation of genes critical to cell migration and extracellular matrix-cytoskeleton coupling, all alterations that provide an impediment to correct angiogenesis.

Among nonstructural proteins, NS4B and NS5A are able to induce ER membrane alteration, called membranous web, that provide a scaffold for the assembly of the HCV replication complex and protection from host immune defenses [ 18, 19].

The reduced proliferation of CD8 T cells from the BDE-209-exposed mice could be due to an intrinsic defect of the CD8 T cells or to alterations of other cell types that provide second (costimulatory) and third (cytokine) signals in addition to the T-cell receptor signal provided by anti-CD3 and anti-CD28 mAb in the in vitro stimulation assay.

These alterations target genes that influence networks that provide the tumors with a selective advantage over cells of normal composition.

It is possible that the very initial genetic alterations in tumorigenesis, presumably the ones that provide proliferation advantage, may also enable cell dissemination.

Computational analysis suggested structural alterations that could provide additional interactions with RT and thus improve inhibitory potency.