The phrase "alterations that further" is correct and usable in written English.
It can be used when discussing changes or modifications that enhance or advance a particular situation or outcome.
Example: "The report includes several alterations that further improve the overall efficiency of the system."
Alternatives: "changes that enhance" or "modifications that advance".
sTn is also a biomarker of concomitant molecular alterations that may further determine the tumour behaviour (Ohno et al, 2006).
Although we did not assess electrical conduction in the present study, exposures to O3, PM2.5, or O3 + PM2.5 may initiate ECG alterations that were further modified in HFrD rats to decrease heart rate.
The aim of our study was to examine the gross genomic changes present in order to identify structural and numerical alterations that may warrant further investigation using higher resolution molecular techniques.
Further, alterations that are critical for development of an invasive phenotype may occur in DCIS and once the cancerous cells escape from the duct additional epigenetic programming may be required for further progression or metastasis.
The genetic alterations that we identified were further validated through next-generation sequencing (NGS) and their association with a specific clinical stage was confirmed by comparison with 36 atypical hyperplasia (i.e. premalignant) tissues.
Although a direct role cannot be inferred, these results support the hypothesis that increases in the fraction of diploid cells is an important early event in the development of rat HCC and that further alterations in DNA ploidy and increased proliferative fraction accompany the development of HCC.
Once this is obtained, cells can accumulate further genetic alterations that drive progressive transformation into highly malignant derivatives.
This then brings about further chromatin alterations that permit recruitment of additional DDR mediators such as p53-binding protein 1 (53BP1) and breast cancer 1 (BRCA1; Panier and Durocher, 2009).
In order to identify further molecular alterations that might be associated with the cytoskeletal disorganisation, we used isobaric tags for relative and absolute quantitation (iTRAQ) mass spectrometry proteomics to compare global protein abundance in sciatic nerves from 6-week-old heterozygote (asymptomatic) and Rab18 −/− (symptomatic) mice (n=3 per genotype).
