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Cancer results from cellular mutations that enhance proliferation, decrease tumor suppressive signals, and decrease programmed cell death; and from cellular alterations that enhance angiogenesis and metastasis [ 1].
Expression of variants of murine anti-DNA antibodies has shown that sequence alterations that enhance binding to dsDNA do not necessarily increase pathogenicity [ 20].
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These data suggest that aging leads to alterations in DNA that enhance its immunogenicity, and may contribute to age-associated chronic inflammation and autoimmune phenomenon.
Breast cancer displays frequent intra- and inter-tumor heterogeneity as the result of genetic and non-genetic alterations that often enhance the vigor of cancer cells.
On the other hand, recent researches show that HIF-1 inhibition results in metabolic alterations that could enhance the therapeutic efficacy of radiotherapy [ 78, 79].
A third possibility is side effects: alterations that neither enhance the success of the oncogenic instruction nor protect the host from it (categories adapted from Ewald 1980).
This suggests a model in which adaptive immune resistance mechanisms may be followed by somatic genetic alterations that further enhance tumour immune escape.
Chemokines are primarily involved in the recruitment of immune cells to inflammatory sites [ 50, 51], and their increased expression indicates that weaning stress results in transcriptional alterations that may enhance leukocyte recruitment and activation.
We found, in both organisms, that alterations in genetic background that enhance the aggregation phenotype were enriched for multiple genes that directly or indirectly influence transcript and protein availability.
The regulation of mRNA translation efficiency can occur by a variety of mechanisms, one of which includes alterations in the mRNA sequence that enhance translatability [ 47].
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