Sentence examples for alterations target from inspiring English sources

The majority of these genetic alterations target players in a limited set of signalling transduction pathways or processes [1], [2].

These alterations target genes that influence networks that provide the tumors with a selective advantage over cells of normal composition.

MEMo automatically identifies mutually exclusive alterations targeting frequently altered genes that are likely to belong to the same pathway.

These cancers possessed copy number alterations targeting key loci in human T cell lymphomagenesis.

Alterations targeting the tumor suppressor Pten occurred in the majority of murine SCLC studied, and engineered Pten deletion accelerated murine SCLC and abrogated loss of Chr19 in Trp53; Rb1; Pten compound mutant tumors.

Alterations to pitch setting and twist distribution are shown to have most impact upon the design requirement of increased gradient in the rotor speed-efficiency relationship in the overspeed region; coupled with such alterations, targeted changes to the chord distribution have been shown to increase the maximum efficiency.

The CRC alterations targeted certain chromosomes more than others.

Genetic alterations targeting the EGFR signaling pathway appear nearly constant in tumors with genomic instability.

pRb can also be indirectly inactivated in other tumor types as a consequence of alterations targeting genes coding for any of its several upstream regulators such as CDK4, cyclin D and p16ink4a [6].

There are multiple other alterations targeting genes involved in these two well-studied pathways mediated by RB1 and p53; G1/S phase transition during cell cycle progression, affecting CCNE1, RB1, SKP2, and p53, and DNA repair, including FANCA, RAD1, RAD52, XRCC6, and MSH4.

Male breast cancer alterations targeted Xp11.23 and 14q13.1 regions in more than 50% of cases.