Sentence examples for alterations sustained from inspiring English sources

It is known that the genetic and epigenetic alterations sustained by host cells during malignant transformation alter the repertoire of mRNA species available for targeting by miRNAs (Lujambio and Lowe, 2012).

Certain metabolic alterations sustained in obese men, such as increased levels of insulin, insulin-like growth factor-1 (IGF-1), and leptin may increase prostate cancer risk.

Alternatively, it could be that the inherent genetic or epigenetic alterations sustained within the same epithelial target population differ depending on the developmental stage or age of the breast epithelium.

These alterations sustain disease and allow progression; mechanistically, they may also enable development of hormone therapy resistance.

The present study confirms that these alterations are sustained and further identifies the decreased synaptic density as well as alterations to the general morphology of the molecular layer of the cerebellar cortex that are the result of the binge ethanol exposure.

Moreover, in vivo studies further support that angiotensin II induces several vascular alterations including sustained elevations of blood pressure, enhanced inflammatory response, increased medial thickness of the aortas, and formation of aortic dissection and aneurysms.

Abundant data suggest that sepsis induces a myopathy characterized by reductions in muscle force-generating capacity (force generation per cross-sectional area), loss of muscle mass and altered bioenergetics, but the mechanisms by which acute hyperglycemia induces prolonged or sustained alterations in the peripheral nervous system and in skeletal muscle are largely unknown.

Cancers also can be produced in experimental systems in vitro and in vivo, for example, by inducing sustained alterations of extracellular matrix (ECM) structure.

Adaptations of large arteries to sustained alterations in hemodynamics that cause changes in both caliber and stiffness are increasingly recognized as important initiators or indicators of cardiovascular risk to high flow, low resistance organs such as the brain, heart, and kidney.

Scr alterations were not sustained but irreversible in both female and male rats in all dosage XF and PXF groups.

These alterations led to sustained cell-cell interaction and reduced cell motility in endothelial cells, microvascular glEND.2 cells and HUVEC (summarized in Figure  8).