The phrase "alterations such that" is correct and usable in written English.
It can be used to describe changes made to something in a way that results in a specific outcome or condition.
Example: "The alterations such that the system operates more efficiently were implemented last week."
Alternatives: "changes so that" or "modifications to ensure".
In all these cases, we observe general, coordinated alterations, such that the densities of chromatin and non-chromatin proteins vary slightly throughout all SILAC plots (Fig 2F H).
The first premise is that lifespan extension in Snell, Ames, Little and GHR-KO mice is due to shared GH/IGF-I alterations, such that genes exhibiting parallel transcriptional changes in all four models are likely to play an important role in longevity.
Some genetic alterations, such as that of the promoter of the MDM2 oncogene, are able to modify the age of onset of colorectal cancer and probably differentiate prognosis (Menin et al, 2006).
In addition, progression of many diseases leads to tissue alterations, such as fibrosis, that will hamper transplantation of any cell, including reprogrammed ones.
Such genes may provide a target for genome alterations, such as gene decay, that would be under no selection.
This observation indicates that the most important common denominator of cell lines at a molecular level are gene alterations linked to their immortalisation (an essential feature of any type of cancer cell line), which, in terms of gene expression, apparently overrule type-specific gene alterations, such as chromosomal translocations that define the respective clinical entities.
Mean velocity (Vmean), average portal blood flow volume (PBFV) and congestion index (CI) are important indicators in hepatic evaluation, mainly to detect alterations such as chronic hepatic diseases that lead to portal hypertension [ 1].
These observations have implicated specific recombination proteins and also highlighted other alterations, such as defects in mismatch repair, that may similarly influence the survival of human cells that fail to express telomerase.
However, microscopic alterations such as dendritic and synaptic changes that have been documented in uncomplicated alcoholics [22] might, more likely, underlie episodic memory dysfunction.
The drug might also be effective in other organs that show cystic alterations such as breast and ovaries [ 23].
It is known that epigenetic alterations, such as global hypomethylation, regional hypermethylation of tumor suppressor genes, and histone modification that alters chromatin structure, are involved in HCC.
