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Dogs with DCM showed more strongly defined degenerative changes than the CMVD dogs (median nuclei enlargement score 3 vs. 1, median loss of striation score 3 vs. 2 and median structural alterations score 3 vs. 2, respectively; p < 0.05).
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These items were summed to the taste alteration score, which has already been used in previous studies [ 21, 22].
In each section, a global alteration score of each inflammatory abnormality was calculated as the sum of the areas obtained.
All items are rated on a Likert scale ranging from 0 to 3. Sum scores <8 indicate normal range; scores from 8to1010 reflect mild alterations and scores ≥11 indicate clinical relevance of symptoms [ 13].
Alterations were scored with an empirical interval score for each of the different anatomical elements in the fetal trachea (epithelium, submucosa, cartilage, pars membranacea).
Deoxyhemoglobin concentration alteration (DeHCA) score in malignant lesions was significantly higher than that in benign lesions.
Deoxyhemoglobin concentration alteration (DeHCA) score in malignant lesions was significantly higher than that in benign lesions The accuracy of DeHCA score was significantly lower than that of mammography and/or ultrasound (US) DeHCA score accuracy linearly combined with mammography or US was significantly higher than DeHCA score alone, but not significantly higher than mammography or US alone.
An alteration frequency score for each gene was calculated, based on the 84 GBM cases with both sequence mutation and copy number data (hypermutators excluded).
Regressive cytonuclear alterations were scored if marked anisocytosis, vacuolisation and increase of nuclear size was seen in residual tumour cells.
Many assays for oncogenic transformation have been developed ranging from those in established rodent cell lines where morphological alteration is scored, to those in human cells growing in nude mice where tumor invasiveness is scored.
The extent of alteration was scored as severe, moderate, mild, and not found.
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