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We investigated whether such manipulation could induce behavioural alterations relevant to the modelling of ADHD, in particular symptoms of hyperactivity and impulsivity.
Studies in animal models of maternal infection have demonstrated a plethora of behavioral, molecular and structural alterations relevant to schizophrenia in the adult offspring [5] [16].
This finding validates the performance of both technologies in identifying alterations relevant to sickle cell disease.
Metabolic alterations relevant to postprandial dyslipidemia were previously identified in the intestine of obese insulin-resistant subjects.
By evaluating global gene expression changes pre- and post-treatment, we have developed a profile of gene alterations relevant to SINE compound response and the development of resistance.
We developed a tumor-genotyping panel to screen lung cancer patients for genetic alterations relevant to novel molecular-targeted therapeutics in ongoing clinical trials [ 12– 15] (Additional file 1: Table S1).
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Further studies are needed to establish whether these alterations are relevant to the increased cardiovascular risk in RA.
Many genetic alterations are relevant to the accurate classification of leukemia and they sometimes can generate multiple transcript variants challenging to detect with sequence-specific molecular methods.
Calcium depletion induced ER redox alterations are relevant to physiological conditions associated with calcium signaling, such as the response of pancreatic cells to secretagogues and neuronal activity.
Thus, this system offers the unique opportunity to compare two clonally expanding cell populations, normal and nodular hepatocytes, in vivo and possibly to dissect the biochemical and/or molecular alterations critically relevant to their different phenotypic behaviour (Marongiu et al. 2008).
These alterations may be relevant to the pulmonary dysfunction after induction of SAH.
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