Sentence examples for alterations progress from inspiring English sources

7 8 These secondary alterations progress with age 9 and contribute to a gradual loss of functional capacity, 10 characterised by deterioration in gait 11 12 and reduced muscular strength 13 throughout adolescence and young adulthood in individuals with CP.

As the knowledge on cancer genetic alterations progresses, it fosters the need for more personalized therapeutic intervention in modern cancer management.

Josephine Dorsman and colleagues explored the nature of this heterogeneity and drew the conclusion that retinoblastoma tumors start as smaller, more differentiated tumors with fewer somatic DNA copy number alterations and progress towards larger, less differentiated, more proliferative and more genomically instable tumors [62].

Nishida et al report that aberrant methylation of a limited number of loci is common in the normal ageing liver and that these epigenetic alterations gradually progress and expand to a larger panel of methylation markers in HCC.

The transformation of glass into secondary minerals does not significantly change the porosity, which allows the alteration to progress.

The partially methylated cells then could acquire a somatic second "hit" (a mutation or a second epigenetic alteration) to progress to cancer [ 60].

Early detection of pressure ulcer has been emphasized because it could prevent skin alteration from progressing to skin loss.

To date, no information was available on cardiac structure and function in individuals with combined IFG and IGT, a condition characterized by profound metabolic alterations that rapidly progress to diabetes.

Since tumors undergo continuous alterations as they progress, the tumor site can be considered as a place where a never-ending deconstruction and reconstruction takes place and the tumor itself is the architect.

We compared gene alterations in tumors progressing on therapy (PD) versus tumors not progressing (stable disease or an objective response) classified according to the UICC criteria [ 30] as previously described [ 10, 31].

As the result of multiple alterations, mammary cancer progresses through multiple stages in a multistep process that drives normal breast cells into highly malignant cells.