Sentence examples for alterations plays a from inspiring English sources

Genomic instability reflecting the susceptibility of the genome to acquire multiple genetic alterations plays a major role in tumorigenesis and tumor progression.

Lastly, a comparative analysis between differential gene expression in CIS lesions and invasive carcinoma with array CGH data from independent CIS specimens, suggests that copy number alterations plays a significant role in differential gene expression in CIS lesions.

Acquisition of somatic genetic alterations plays an important role in the development of cancer.

Recently it became apparent that not only genetic but also epigenetic alterations play a major role in carcinogenesis.

Introduction: Chloride alterations play a major physiologic role in the development of acid base disorders.

While it seems clear that serotonergic alterations play a role in the pathogenesis of these major public health problems, dysfunction in additional neurotransmitter systems and other molecular alterations may also be implicated.

Of particular importance are the MAPK and PI3K/Akt pathways, which, through their genetic alterations, play a critical role in the development and pathogenesis of melanoma and are therefore tested vigorously as important therapeutic targets for this cancer [6], [10] [15].

All the hypermutator strains were the result of a deficiency in MRS, and despite most reports have described mutations in the mutS gene as the main cause of hypermutability, followed by mutations in mutL and uvrD [18], [20], in our collection, mutations in mutL were actually the most frequent cause of MRS deficiency, with the mutS gene alterations playing a secondary role (Table 2).

Microcirculatory alterations play a pivotal role in sepsis and persist despite correction of systemic hemodynamic parameters.

Clearly, genetic alterations play a role in pancreatic fibrosis of this rat strain.

Genomic and molecular alterations play a significant role in breast cancer biology.