Sentence examples for alterations play important from inspiring English sources

Preclinical models have revealed that histone gene modifiers and epigenetic alterations play important roles in renal cell carcinoma (RCC) tumorigenesis.

These alterations may play important roles in cancer [ 2, 3].

Preclinical models have revealed that histone gene modifiers and epigenetic alterations may play important roles in RCC tumorigenesis and progression.

These hormonal alterations may play important role in the patterns of circulating miRNAs reported in the present study, as it has been previously shown that groups of miRNA may regulate or are regulated by endocrine signals (Poy et al., 2004).

Perlecan is a critical regulator of growth factor-mediated signaling and angiogenesis, and is fundamental for the maintenance of basement membrane homeostasis [ 30], and as such its alteration could play important roles in IDC progression.

Based on the general assumption about the impact of CpG island methylation on gene silencing [ 6, 28], we expected that this epigenetic alteration might play important roles in transcriptional repression of TTC40 in NPC tumors.

This indicates that besides the oxidation mechanism, enzymatic alterations may also play important roles in the induced dopamine depletion.

Several important physiological functions require the cooperation of microbiota/microbiome, whose alterations play an important role in several human diseases.

Its alterations play an important role in tumorigenesis and tumor-suppression.

While many of the key mechanisms underlying its carcinogenic effects remain unknown, there is increasing evidence that chromosomal alterations play an important role in the development of the induced leukemias.

Epigenetic alterations play an important role in the molecular pathology of GBM.