Sentence examples for alterations over a from inspiring English sources

The presented case study deals with the hydromorphological alterations over a period of nearly 400 years and their ecological effects as shown by macrophytes in the urban floodplain Lobau along the Danube River within the city limits of Vienna for a period of about 160 years.

Dose-response curves for DNA adducts and genetic alterations over a low dose range.

The development and progression of ESCC stages, including single hyperplasia and single squamous metaplasia, atypical hyperplasia and allotype squamous metaplasia, in situ carcinoma, infiltrating carcinoma, and metastatic carcinoma, may involve the accumulation of multiple genetic alterations over a long period of time [ 40].

There is limited information about these alterations over an extended period of time.

In order to identify a given set of genes that exhibited major alterations over time, a model-based clustering method [ 30] was employed, and the genes in the cluster were considered as differentially expressed over the time period.

Intensive care has undergone several alterations over time as a function of increasing medical knowledge and technological advancement [ 1].

CYT-1 ERBB4-induced tumors may develop either directly by sustained and enhanced downstream ERBB4 signaling in a FVB genetic background, or from ERBB4 signaling acting in concert with secondary genetic or epigenetic alterations acquired over a 1-year period.

One of the steps towards attaining this goal has been the development of inducible systems that allow genetic alterations to be confined to the prostatic epithelium of the mature gland, the target tissue involved in the acquisition of genetic alterations over the span of a human lifetime.

Cancer mutations in protein kinases could often exemplify the phenomenon of oncogene addiction whereby, despite the accrual of numerous genetic alterations over the maturation of a tumor, cancer cells could remain reliant upon particular oncogenic pathways and may become addicted to the continued activity of specific activated oncogenes [33], [34].

These questions can be addressed in laboratory studies in experimental models and in clinical trials with human subjects with end points such as circulating hormone level alterations over the course of a 24-hr period.

Since RNO10, 12 and 20 displayed the most recurrent alterations (over 20%) in the M-CGH analysis we chose an average distance between BAC clones of 0.46 to 0.92 Mb for these three chromosomes on the array.