Sentence examples for alterations on specific from inspiring English sources

Thus, the LDGs displayed a marked increase in somatic alterations on specific chromosomes when compared to either autologous normal-density neutrophils or healthy controls.

DOI: http://dx.doi.org/10.7554/eLife.06394.011 10.7554/eLiFigure94 figuregure 4—figure supplement 2. Strong correlation between the presence of Hairy binding and chromatin alterations on specific chromatin blocks.

These findings are consistent with the alterations found on specific regional brain activity both by lesion studies as well as by functional imaging studies that implicate the prefrontal and the nondominant parietal cortices.

In the current study, we applied GAP [ 13] to SNP array data in combination with conventional DNA-FCM to analyze genomic alterations on an allele specific level, patterns of tumor ploidy, tumor subclonality and fraction of aberrant cells in a large set HER2-amplified and HER2-negative tumors stratified by molecular subtype.

Genetic alterations and/or deregulations of tumor suppressors or oncogenes often drive metabolic reprograming in cancers, although this effect can differ based on specific alterations or deregulations, and is often context-dependent.

While the TCGA study contained eight male breast cancers (MBCs), the analysis neither segregated nor commented on specific alterations in males.

8, 9 Clear-cut evidence on specific alterations of cholesterol metabolism associated with old age is presently missing, mainly due to the complexity of the studies of clinical pathophysiology and, consequently, to the limited number of observations.

This combined approach thereby provides greater insight into the similarities and differences of related cancers, and how these features can guide targeted intervention not only based on specific genetic alterations but also on all alterations that can contribute to an alteration of targeted genes and pathways.

In conclusion, the new factor TNSA based on specific genomic alterations could independently predict metastasis occurrence, OS, CSM, CSS and PFS in patients with ccRCCs.

Epigenetic diversity has been reported to accumulate in brain cells, germ cells, peripheral blood cells and other tissues over time [ 95- 97], although the effects of aging on specific epigenetic alterations are unclear.

Based on specific genetic alterations found in the different types of DCIS, a more likely scenario is the evolution of well-, moderandly, and poorly differentiated DCIS via distinct pathways.