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A third cluster (CIN-very Low or CIN-VL) included tumors with a very low number of alterations: on average 29% of loci were altered (14%-48 14%-487).
One cluster (CIN Low or CIN-L) had tumors harboring a low number of alterations: on average 43% of the loci were altered (27%-71 27%-7111), and they were mainly altered at markers on 8p (D8S264), 17p (TP53, close to the p53 gene), 18q (D18S61, D18S53), and 20q (D20S107).
A second cluster of tumors (CIN-High or CIN-H) harbored a large number of alterations: on average 72.8% of the loci were altered (38%-100%; n = 15), and the alterations were widely distributed among all MS, but also included alterations on 8p, 17p, 18q, and 20q.
In contrast, norm 7/8 tumours exhibited only 5 10% Mib-1 staining and 5.3 genetic alterations on average per case.
The gain 7/8 tumours displayed more than 20% Mib-1 staining and more than 12 genetic alterations on average per case as revealed by CGH analysis.
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The depth of the thermal alteration was on average 4 mm larger using the newly tested instrument.
The depth of the thermal alteration was on average 4 mm larger in group A using the newly tested instrument; dispersion of values was 12 17 mm.
After sequencing of 20 661 genes, 63 genetic alterations were found on average in each pancreatic cancer belonging to a set of 12 signalling pathways altered in greater than two-thirds of tumours (Jones et al, 2008).
On average, alterations in plaque morphology were much more pronounced in chicken-passaged SLEV (data not shown).
Recent large scale analysis of gene mutations, deletions, and amplifications in human tumors have revealed that cancers exhibit on average ∼60 90 genetic alterations per tumor [1], [2].
On average, 16.6 CGH alterations per case were detected.
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