The phrase "alterations of which" is correct and usable in written English.
It can be used when referring to changes or modifications related to a specific subject previously mentioned.
Example: "The report included several alterations of which the committee was unaware."
Alternatives: "changes of which" or "modifications of which".
Interestingly, AKT2 amplification seen is a critical component of the PI3K/mTOR pathway, alterations of which has been associated with both de novo and acquired resistance to targeted therapy.
BDNF plays an important role in regulating dopaminergic, glutamatergic, and other neuronal signaling pathways, alterations of which are observed in schizophrenia [41] [42].
Here, we report a total of 14 BRCandand 17 BRCA2 sequence alterations, of which eight are novel (3 BRCandand 5 BRCA2).
Study of the role of these factors in the context of various cellular processes, alterations of which, underlie the pathogenesis of several diseases is an area worthy of investigation.
We found a total of four previously unknown EPHB2 germline alterations, of which three may associate with the disease phenotype.
Seventy-eight were single base pair alterations, of which 23 were missense mutations; 55 were distributed across conserved intronic regions or the 5' and 3' regions.
These findings indicate that the selection of an AUG codon depends on numerous variables, alteration of which can redirect translation initiation.
Importantly, we also identify a novel gene module within the insulin growth factor signalling pathway, alteration of which may predispose the tumour to metastasize.
Different deubiquitinating enzymes may be critical in balancing c-Cbl and SMURF2 activity [ 43], thus tightly regulating EGFR protein stability, alteration of which during oncogenesis leads to EGFR overexpression.
The clinical importance of this finding is unclear: a compensatory mechanism cannot be excluded although unable to restore the physiological bone metabolism (the alteration of which could only be overcome by much larger PTH peaks such as those obtained by exogenous administration).
Last year, the synagogue received permission from the Landmarks Preservation Commission to make alterations, one of which involved building a brick-clad structure in its side and rear yards.
