The phrase "alterations of two" is not standard and may cause confusion in written English.
It could be used in contexts discussing changes or modifications involving two items or elements, but clarity is essential.
Example: "The alterations of two key variables in the experiment led to unexpected results."
Alternatives: "changes involving two" or "modifications of two."
Clinicopathological features and molecular genetic alterations of two types of ovarian carcinoma are summarized in Table 1.
We found concordant and consistent alterations of two genes in 90% of IBC tumors when compared with stage-matched non-IBC tumors: overexpression of RhoC guanosine triphosphatase and loss of WNT-1 induced secreted protein 3 (WISP3).
The RB1 gene could be inactivated by a combination of genetic and epigenetic alterations of two alleles; in fact, the RB1 gene harbours a CpG island that encompasses the essential promoter region, which is unmethylated during development (Jones, 1996).
Guo-Min Li (University of Kentucky, Lexington, Kentucky, USA) observed genetic and epigenetic alterations of two mismatch repair genes, h MSH2 and h MLH1, in sporadic breast tumors with microsatellite instability.
As changes in the observed PPR between control and PrP3F4 expressing synapses could be caused by alterations of two different parameters, namely: (i) the initial pvr of the synapse but also (ii) the size of the ready-releasable pool (RRP) (43, 47, 48), it is important to estimate both of these synaptic parameters.
The alterations of three highly conserved residues in LATS1/2-A77/76P-I81/80T-L85/84P prevented its interaction with Merlin/NF2, membrane localization and activation (Yin et al., 2013).
By IPA analysis, plasma proteome changes in malaria-infected primigravidae with SA resulted in alterations of five canonical pathways, most significantly the acute phase response signaling pathway.
Furthermore, the current study is limited to examine the alterations of four tight junction proteins.
These engineered transforming mutations result in major alterations of three signaling pathways that are crucial to human GBM (TCGA, 2008).
To investigate this, we comprehensively investigated genetic and epigenetic alterations of three loci – WT1 (11p13), WT2 (11p15.5), and CTNNB1 (3p21) — in 35 sporadic Wilms' tumours.
To illustrate the similarities and differences between the four subgroups of 1p/19q non-co-deleted gliomas, we examined the pattern of alterations of three well-described glioma associated genes.
