Sentence examples for alterations of transcript from inspiring English sources

Instead, it can also involve weak but consistent alterations of transcript abundance.

This design is well suited to study length-dependent alterations of transcript abundance due to RNA degradation and imperfect amplification.

Transcriptome studies have shown that large scale alterations of transcript abundances is a common feature of Fe deficiency and thus plays a key role in the Fe deficiency response [ 15- 17].

A correlation between alteration of transcript levels and corresponding proteins was detected for half of the differentially regulated proteins.

Further modifications, including alteration of transcript splicing sites, modification of codon usage patterns, and the introduction of introns into TMV coding sequences, have improved protein expression further.

In addition, ectopic expression of this gene altered plant development including plant height, internode length, and size of leaves and flowers, accompanied by alteration of transcript abundance of the gibberellin biosynthesis-related gene GA2OX3.

This partial loss of imprinting results in alteration of transcript dosage of chromosome 12-imprinted genes, and the mice are viable and fertile (Schuster-Gossler et al., 1998; Sekita et al., 2006; Steshina et al., 2006).

RT-PCR analysis showed that steady-state mRNA levels of these genes were higher in the transgenic plants compared with those of WT in the absence of water stress, in line with earlier reports in which overexpression of a TF resulted in extensive alteration of transcript levels of an arsenal of related genes [ 33, 34].

However, such a pro-angiogenic pattern of SSc-MVECs is counterbalanced by up-regulation of pent(r)axin 3, a powerful angiogenesis inhibitor, by down-regulation of a few critical pro-angiogenic transcripts (three tissue KLKs, plexin-B1, and DSG), and by alteration of transcripts involved in signal transduction pathways.

Candidate genes with a P-value threshold of 0.05 are presented in Table 3. qPCR analysis confirmed significant alteration of transcripts encoding α1-antitrypsin, α2-macroglobulin, fibrinogen α, immediate early-response genes Egr-1 and IER-5, pro-inflammatory cytokine IL-32, and hypoxia-related bHLH transcription factors Hes-1, DEC1 and DEC2.

The observation of genotype-dependent alterations of Homer1 transcript levels thus suggests that A53T-SNCA overexpression affects glutamate neurotransmission throughout the brain and that Homer1 expression is a useful marker of this effect.