The phrase "alterations of three" is correct and usable in written English.
It can be used in contexts where you are discussing changes or modifications that involve the number three, such as in mathematics, design, or any field where alterations are quantified.
Example: "The alterations of three in the design significantly improved its functionality and aesthetics."
Alternatives: "changes involving three" or "modifications of three".
The alterations of three highly conserved residues in LATS1/2-A77/76P-I81/80T-L85/84P prevented its interaction with Merlin/NF2, membrane localization and activation (Yin et al., 2013).
These engineered transforming mutations result in major alterations of three signaling pathways that are crucial to human GBM (TCGA, 2008).
To investigate this, we comprehensively investigated genetic and epigenetic alterations of three loci – WT1 (11p13), WT2 (11p15.5), and CTNNB1 (3p21) — in 35 sporadic Wilms' tumours.
To illustrate the similarities and differences between the four subgroups of 1p/19q non-co-deleted gliomas, we examined the pattern of alterations of three well-described glioma associated genes.
In this study, we investigated genetic and epigenetic alterations of three loci that are thought to be involved in Wilms' tumour: the WT2 locus (11p15. 5) including the IGF2/ H19 and the KIP2/ Limprintedntedomainsns, the WT1 locus (11p13) including the WT1 gene, and 3p21 locus including the CTNNB1 gene.
Alterations of three Akt isoforms, including amplification of Akt1, somatic (activating) mutations of Akt1,amplification of Akt2, overexpression of Akt2 without evidence of Akt2 amplification, overexpression of Akt3 mRNA and protein but lack evidence of Akt3 amplification, and somatic (activating) mutations of Akt3 have been reported in a wide range of tumour types [ 41- 46].
By IPA analysis, plasma proteome changes in malaria-infected primigravidae with SA resulted in alterations of five canonical pathways, most significantly the acute phase response signaling pathway.
Furthermore, the current study is limited to examine the alterations of four tight junction proteins.
Clinicopathological features and molecular genetic alterations of two types of ovarian carcinoma are summarized in Table 1.
We found concordant and consistent alterations of two genes in 90% of IBC tumors when compared with stage-matched non-IBC tumors: overexpression of RhoC guanosine triphosphatase and loss of WNT-1 induced secreted protein 3 (WISP3).
The RB1 gene could be inactivated by a combination of genetic and epigenetic alterations of two alleles; in fact, the RB1 gene harbours a CpG island that encompasses the essential promoter region, which is unmethylated during development (Jones, 1996).
