Sentence examples for alterations of synaptic from inspiring English sources
Our results revealed alterations of synaptic neurotransmission and intracellular signaling.
Studies in the 6-OHDA rat model of Parkinson's disease have demonstrated that LID are associated with alterations of synaptic plasticity in corticostriatal synapses (Picconi et al., 2003).
In conclusion, we demonstrated for the first time that visceral hypersensitivity is associated with alterations of synaptic plasticity in the ACC.
Indeed, there are no doubts that a complex alteration of transportation and distribution occurs in the AD brain and that alterations of synaptic Zn2+ are key factors in promoting AD-like pathology.
It engages in these tasks by means of long-term alterations of synaptic efficacy in the form of synaptic plasticity (Martin and Buno 2005; Kemp and Manahan-Vaughan 2007), network oscillatory activity (Buzsaki and Draguhn 2004; Hasselmo 2005), and place field formation (O'Keefe and Dostrovsky 1971; Knierim et al. 1995).
Although several alterations of synaptic plasticity have been reported in IP3R1KO hippocampal neurons such as LTD-LTP conversion (Nishiyama et al., 2000) and LTP facilitation in excitatory synapses (Fujii et al., 2000, Itoh et al., 2001), the mechanisms underlying these modifications mostly remain unknown.
These mutations result in a loss-of-function of the alpha(2) Na/K-ATPase with glutamate accumulation, alteration of synaptic function and neurotransmission.
The novel mutation may result impaired M9 transmembrane domain, in a loss-of-function of the alpha(2) Na/K-ATPase with glutamate accumulation, alteration of synaptic function and neurotransmission.
Growing evidence supports a role for alteration of synaptic function in AD.
Deferred alteration of synaptic function depending on prenatal development has already been observed.
Microglia are the instrumental cells of brain inflammation, therefore we investigated here the relationship between prenatal activation of microglia and alteration of synaptic function.
