The phrase "alterations of specific" is not correct and lacks clarity in written English.
It may be intended to refer to changes or modifications that are particular or defined, but it needs additional context to be meaningful.
Example: "The alterations of specific parameters in the experiment led to unexpected results."
Alternatives: "modifications of particular" or "changes to specific".
Apparently minor alterations of specific MICOS subunits alter its stability in such a way that in the absence of Aim24 mitochondria are unable to maintain respiratory growth.
In a few primary metabolic disorders, small genetic mutations lead to structural alterations of specific proteins that disrupt protein function and are responsible for the disease state.
Constitutive activation of wnt signaling is a common event in human cancers, and alterations of specific pathway components have been implicated in diverse tumor types [37].
This study shows that, already in prepubertal age, obesity is linked with hyperleptinemia, impaired HMW adiponectin levels, as well as alterations of specific immune mediators with minor sex-associated differences.
Furthermore, we were able to detect sustained alterations of specific microRNAs in different scenarios, including longitudinal and cross-sectional expression analyses as well as in animal studies.
Alterations of specific sequences in the hACHE-S and oACHE-S genes were introduced by site directed mutagenesis as follows (for the oligonucleotides used, see Table 2).
The Aye lab has developed a novel chemistry-driven technique aimed at directly linking individual biological responses to chemical redox alteration of specific target proteins.
The physical basis for the increase in infectious titre seen after exposure to pronase E remains unexplained, but may reflect changes in PrP aggregate size with concomitant alteration of specific prion infectivity [8] or increased bioavailability of prions following removal of other proteins.
Knockout and mutant mouse models of sodium channel α subunits demonstrate varying degrees of adverse outcomes associated with loss or alteration of specific channel subunits.
However, our results suggest an alteration of specific neuropeptide pathways, rather than the general effect of a chemical, such as an OP insecticide, interfering with neuronal signaling.
