The phrase "alterations of small" is not correct and does not convey a clear meaning in written English.
It may be intended to refer to minor changes or adjustments, but the phrasing is awkward and unclear.
Example: "The alterations of small details in the design made a significant impact on the overall appearance."
Alternatives: "minor adjustments" or "small modifications".
Similar observations on the ligand-receptor subtype selectivity were highlighted for other GPCR families such as the nociceptin δ-OR receptors: although presenting high residue conservation on their ligand binding site, ligand selectivity for those receptors was based on a few critical alterations of smaller to larger residues.
Plasma citrulline concentration might be decreased among critically ill patients presenting with sepsis, reflecting an alteration of small bowel function.
The complete alteration of small glassy fragments is rather fast, from a few days to a few hours, due to a low grain size, high surface roughness, and high temperature.
An extensive alteration of small intestinal brush border enzymes between GF and ex-GF piglets has also been noted [ 48].
Alteration of small RNA in S. aureus and its role in gene expression has been extensively studied [ 38, 39].
The finding that minor alterations of the small Domain 2 (introduction of 5 residues in a domain of ∼50 amino acids) influence secretion was unexpected as we assume that the overall modification of the tertiary structure is minimal.
Serological markers facilitate the recognition of CD cases, but definitive diagnosis requires histological alterations of the small bowel mucosa [ 4].
Structural alterations of the small vessels in diabetes have been incriminated in the development of diabetic cardiomyopathy, although this remains controversial.
Alterations of the small bowel mucosa could be responsible for decreased intestinal Apo A-I secretion and, consequently, for reduced HDL synthesis (4).
