Sentence examples for alterations of nuclear from inspiring English sources

We investigated if different mutations of ATM could reflect on different alterations of nuclear architecture and chromatin organization.

ALS-CSF has been shown to produce toxic effects on motor neuron cells like aberrant neurofilament phosphorylation and morphological alterations of nuclear and soma size.

We discuss morphological constraints and epigenetic impacts on nuclear architecture, the evolutionary stability of CT arrangements, and alterations of nuclear architecture during transcription and repair.

We recently showed that fluorescently labelled and unlabelled amorphous silica-NPs enter cells in culture, translocate to the cell nucleus and induce unique alterations of nuclear structure and function [12], [13].

In addition, DNA-specific Hoechst staining revealed clearly evident alterations of nuclear morphology (see below).

Oncogenic signaling has been found to influence nuclear morphology [8]– [10], and alterations of nuclear matrix protein have also been suspected to play a role [5].

We propose that alteration of nuclear compartmentalization might represent an additional common mechanism of leukemogenesis.

Morphological changes of cell through alteration of nuclear content and mitochondrial membrane potential were also examined using Hoechst and JC1 stains under fluorescence microscopy, respectively.

These signals are responsible for a change in the cytoskeletal structure, leading to alteration of nuclear protein matrix and eventually gene activation or suppression [2],[3].

Overall, our findings identify polyglutamine-dependent inhibition of nucleocytoplasmic transport and alteration of nuclear integrity as a central component of Huntington's disease.

TEM analysis of cells exposed to NPs for 24 h revealed alteration of nuclear morphology but only a marginal presence of individual NPs inside the cells.