Sentence examples for alterations of mutant from inspiring English sources

The functional expression of the mutations in expression systems allows to study the functional alterations of mutant channels and to develop new strategies for the therapy of ion channelopathies, e.g. by designing drugs that specifically suppress the effects of malfunctioning channels.

Previous electrophysiological studies described the alteration of mutant sodium channel gating and demonstrated its responsibility for the phenotype [ 3, 4].

The implications of our findings may lead to new therapeutic targets for HD, including: alteration of mutant huntingtin nuclear localization in response to stress; inhibition of TG2 enzymatic activity (67) or activation of alternative stress response pathways that override or circumvent the function of the huntingtin protein in actin-mediated cell stress response.

In a search for copy number alterations of PTPN11 mutant alleles, we performed sequence analysis in tumor DNA of 9 out of 12 patients diagnosed with a malignancy.

The current explanation for the development of therapy resistance and tumour recurrence invokes genomic alterations and selection of mutant cells carrying a relevant mutation acquired by chance before therapy (Nowell, 1976; Yachida et al, 2010; Sottoriva et al, 2013).

In this study, morphological and cytoskeletal alterations of the rad2C65Δ mutant were observed only after UV irradiation, suggesting that XPG/Rad2p-associated cytoskeletal changes take place exclusively under DNA damage.

Given the strong overlap in gene expression changes between and consistent phenotypic alterations of all three mutants we assumed that plasmid loss has no great impact on the experimental results regarding the ∆ctrA mutant.

Variation of phenotype strength may explain frequencies of mutant alterations sharply below 25% within some crosses (curly, levi, smerz) (Table 2).

To assess whether the alterations in the differentiation of mutant postnatal NSCs were also dependent on the activation of the STAT3 pathway, we exposed Tsc1 control and mutant postnatal NSCs to the STAT3 inhibitor JSI-124 (also known as cucurbitacin) under proliferative conditions.

We further evaluated the alteration of PD mutants in 14-3-3 14-3-3 14-3-3tro.

This result is consistent with the absence of GP activity in P1 muscle, and might indicate an alteration in the translation of mutant mRNA or changes in the stability of the mutant protein.