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Given that our results varied substantially with respect to simulated alterations of model input parameters, more comprehensive clinical evidence is needed in order to achieve higher accuracy within health economic evaluation.
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In this way, statistically suboptimal, manual alterations of models are minimized.
In this way, statistically suboptimal, manual alterations of models can be minimized.
On the other hand, strong similarities in the barrier alterations of the model used here and human AD have been depicted [20] and our model thus appears as among the most suitable and practicable models available [38].
Such pattern is robust to alterations of the model parameters and simulated failures predict altered spatio-temporal patterns that mimic those described for several mutants.
As the time to solve the model was more than enough to address the problem dealt with in practical terms, no further alterations of the model where considered so that the computational time might be shorter.
Several approaches separately either first assess the alterations in each data set and then compare the results from both or assess alterations in GE in genes or genomic regions previously identified by an assessment of CN alterations to model changes in GE based on the CN signals [ 16, 19].
In [ 18- 20], optimization techniques are used to determine which reactions can be eliminated from the original model without a substantial alteration of the model behaviour.
However, these particular associations with the first and second environmental events are not a necessary component of the Model and, if it turns out that these two factors are not relevant, then two suitable alternatives would simply need to be substituted into the equations without any alteration of the Model itself.
Hence, an alteration of the model inputs reflecting the other clinical studies for Asacol might have been even more favorable to Mezavant.
Effects of alterations of gh on model CL and DDR are shown in Fig. S10.
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