The phrase "alterations of liver function" is correct and usable in written English.
It can be used in medical or scientific contexts when discussing changes or variations in how the liver operates.
Example: "The study aimed to investigate the alterations of liver function in patients with chronic hepatitis."
Alternatives: "changes in liver function" or "variations in liver function".
The early phase is usually secondary to an acute obstruction of the bile duct and becomes clinically evident with an increase jaundice and alteration of liver function tests.
These data clearly show that alteration of liver function or portosystemic shunts affects the systemic dose of the drug to be used to reach the levels obtained in the absence of liver failure.
These pathways could be effectors of low-dose mixture toxicity, playing a role in the alteration of liver function and in the regulation of hormones biosynthesis, as previously shown [ 14].
At the RPTD of 60 mg (n=7), two patients had dose reductions (transaminase rise and QTc prolongation), while two patients had dose omissions (both due to alteration of liver function tests).
Main exclusion criteria were evident extrahepatic manifestations (abdominal lymph nodes > 25 mm, pulmonary lesions > 15 mm), severe alteration of liver function (cirrhosis, prothrombin time<50%), active viral hepatitis, portal vein thrombosis, previous liver irradiation, impaired coagulation, significant concomitant disease, history of second malignancy.
After the isoflurane washout period we observed a reduction in sedative drug dosage in 10 patients while two patients were quickly weaned from mechanical ventilation and the target RASS raised to 0. In two patients isoflurane was precautionarily interrupted because of concomitant alteration of liver function and suspected seizures respectively.
Hypotension and alteration of liver functions have been reported as potential adverse effects.
Thus alteration of liver functions greatly affects its responses to metabolic stress, and inversely alteration of energy homeostasis may alter liver cell function.
