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MPO contributes to the effects of oxidation and alterations of lipids and propagation of oxidative stress through chlorinating (halogenating) and peroxidase cycle activities [ 3].
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In females, the increased fat intake reversed the deficiencies in NEFA but worsened the effects on triglycerides and cholesterol; the metabolic mechanisms underlying these interactions remain to be elucidated, but they do imply that the parathion-induced alterations of lipid metabolism contribute to the altered weight gain caused by the high-fat diet.
Pertinently, alterations of lipid profile, including ceramide and ceramidase activities occur in atopic dermatitis (AD).
SREBP1c was down-regulated in PEPCK-silenced animals, suggesting a role for this pathway in the alterations of lipid metabolism.
LPL has linked alterations of lipid metabolism with CLL pathogenesis [25], [26].
Hyperlipidaemia and increased FFA turnover are the primary alterations of lipid metabolism observed in obesity.
These findings once again emphasize pathophysiologic alterations of lipid and amino acid metabolism in both atherosclerosis and cancer.
The atherogenic lipid profile is a common finding during the second half of pregnancy and the mechanisms underlying such alterations of lipid metabolism are not fully understood [ 19, 20].
In comparison to body site-specific controls, we detected marked alterations of lipid contents and composition, especially of ceramides, in lesional and non-lesional skin of atopic dogs.
Hence, we obtained a chain of alterations of lipid specificities or binding capacities, which somewhat, but not fully parallel the import behaviour observed [ 8].
Consistent with the expression changes observed in Mwk Purkinje cells, we identified alterations of lipid levels in the mutant cerebellum including a reduction in distinct ceramides (Fig. 6A).
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