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In females, the increased fat intake reversed the deficiencies in NEFA but worsened the effects on triglycerides and cholesterol; the metabolic mechanisms underlying these interactions remain to be elucidated, but they do imply that the parathion-induced alterations of lipid metabolism contribute to the altered weight gain caused by the high-fat diet.
Pertinently, alterations of lipid profile, including ceramide and ceramidase activities occur in atopic dermatitis (AD).
SREBP1c was down-regulated in PEPCK-silenced animals, suggesting a role for this pathway in the alterations of lipid metabolism.
LPL has linked alterations of lipid metabolism with CLL pathogenesis [25], [26].
Hyperlipidaemia and increased FFA turnover are the primary alterations of lipid metabolism observed in obesity.
These findings once again emphasize pathophysiologic alterations of lipid and amino acid metabolism in both atherosclerosis and cancer.
Similar(44)
Since alterations of lipid-raft-related proinflammatory signaling have been identified as a mechanism through which omega-3 PUFAs exert anti-inflammatory actions, bioactive electrophilic derivatives provide an alternative mechanism to the reported changes in membrane composition and fluidity [ 6, 7].
MPO contributes to the effects of oxidation and alterations of lipids and propagation of oxidative stress through chlorinating (halogenating) and peroxidase cycle activities [ 3].
The association of hyperglycemia with an alteration of lipid parameters presents a major risk for cardiovascular complications in diabetes.
The alteration of lipid density can change the 'effective area' of the headgroup and the orientation/association of water, and therefore the electrostatic fields at the surface of the membranes.
Overexpression of Kilon reduces synapse number at early stages but increases the number of dendritic synapses in mature neurons with the alteration of lipid raft dependence (Hashimoto et al., 2008).
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