Sentence examples for alterations of importance from inspiring English sources

It might be speculated whether up-regulation of α1 VII) in concert with down-regulation of α4(IV) results in alterations of importance for invasiveness.

In the present investigation, we sought to identify genetic alterations of importance for chemotherapy resistance in advanced ovarian cancer, with the ultimate aim to uncover predictive markers.

We selected a homogenous primary tumor material concerning histology, stage and chemotherapy response to create the best opportunities for identifying genetic alterations of importance for resistance.

To create the best opportunities for identifying genetic alterations of importance for resistance, we selected a homogenous tumor material concerning histology, stage and chemotherapy.

Interestingly several of these seem to impact on molecules relevant for chemo response, however, the network of microRNA interactions is extremely complex and thus requires further study to reveal alterations of importance for the clinical management of patients.

Recently, new molecular alterations of major importance in the pathogenic mechanisms of this disease have been discovered, and have revealed the biological heterogeneity of MCL.

Profilings of mRNA and microRNA (miRNA) expressions in human cancer have revealed important alterations that do not only have possible diagnostic and prognostic value but also point toward molecular alterations of mechanistic importance for tumor etiology and progression.

It suggests that alterations in these regions are of importance for the outcome in advanced stage ovarian serous tumors.

That is why I believe the purpose of identifying each one of these alterations has its importance independently of the other.

In conclusion, our findings do not point at a differential expression of these two key components of Notch signaling in non-malignant as compared to malignant human keratinocytes, indicating that alterations in their expression are not of importance for the photocarcinogenesis of human squamous cell carcinomas.

Of importance, H3K27 methylation alterations do not seem to be limited to tumors of the astrocytic lineage, with pediatric medulloblastoma tumors, which are neuronal in origin and occur in the cerebellum, demonstrating H3K27 post-translational modifications through increased EZH2 expression or loss-of-function mutations in KDM6A, which encodes a H3K27me3-specific demethylase [ 17, 51, 59].