The phrase "alterations of histone" is correct and usable in written English.
It can be used in contexts related to molecular biology, genetics, or biochemistry when discussing changes or modifications to histone proteins.
Example: "The study focused on the alterations of histone that affect gene expression in cancer cells."
Alternatives: "modifications of histone" or "changes in histone".
However, whether metals in inhalable PM induce alterations of histone modifications in human subjects has never been evaluated.
MS-based analyses were used to quantify global alterations of histone PTMs in colorectal cancer (CRC) samples.
Thus, it is likely that alterations of histone modifications are responsible for KRT13 gene repression in OSCC cells.
In the present study, we used MS-based analysis to quantify global alterations of histone PTMs in matched normal and colon cancer samples.
Also, ketamine causes the alterations of histone deacetylase (HDAC) activity and (BDNF) brain-derived neurotrophic factor in the prefrontal cortex, hippocampus, amygdala, and nucleus accumbens [ 35].
However, the deregulation of epigenetic processes such as DNA methylation and alterations of "histone code" are equally important oncogenic factors per se [ 1– 4].
Such a possibility is evident from a recent study by Kaliman et al. [ 82], where intensive practice of mindfulness meditation resulted in alterations of histones H4ac and H3K4me3, as well as in decreased expression of histone deacetylase genes (HDAC 2, 3, and 9) and pro-inflammatory genes (RIPK2 and COX2) in meditators compared to control individuals.
Together these observations suggest that somatic alteration of histone H1 genes may potentially result in altered nucleosome packing, as well as affecting DNA and/or histone methylation.
Jiang, L., Wang, Y., Zhu, D., Xue, Z. & Mao, H. Alteration of histone H3 lysine 9 dimethylation in peripheral white blood cells of septic patients with trauma and cancer.
The same kind of stresses that activate natural genetic engineering lead to major changes in epigenetic chromatin formatting: loss of DNA methylation and alteration of histone modifications.
Beside the reduced acetylation of histone H3 and H4 in A2780 cells, the patterns of histone modification at the GATA6 locus (Figure 5E) is similar between HOSE cells and cancer lines OVCAR3 and OVCAR10 (Figure 5F), suggesting the alteration of histone modification at GATA6 locus is not a general event in ovarian epithelial and cancer cells.
