Sentence examples for alterations of genomic from inspiring English sources

Epigenetic changes are alterations of genomic function not modifying gene structure as such.

The structure of the human genome is highly variable and the copy number variations (CNVs) refer to alterations of genomic segments of more than 1,000 nucleotides that are present at significant frequencies within a population [ 17- 19].

Besides the alterations of genomic miRNA copy numbers and modifications of the miRNA processing machinery, miRNA deregulation can also be due to epigenetic changes, such as the methylation status of miRNA loci (Yanaihara et al, 2006; Bandi et al, 2009; Farazi et al, 2011; Heller et al, 2012).

These precision engineering techniques can supplement genetic engineering to bring out alteration in specificities of enzymes and change the host's tolerance to various stress levels by specific alteration of genomic regions.

Most often, targeted alteration of genomic DNA in mammalian cells occurs at frequencies that are only detectable by highly sensitive assays.

Alteration of genomic sequences can be detected based on the comparison of Poisson processes associated with the read counts of a case and a control sample [ 13], but this cannot be applied to the detection of transcribed regions in a single condition.

(PDF 9017 kb) Additional file 2: Additional Tables S1-S8: Copy number alterations of known genomic locations identified in HNSCC cell lines.

For instance, it could be assumed that in the tumour cells mutations or alterations of the genomic profile making them more sensitive to sorafenib could have occurred.

Quantitative Polymerase Chain Reaction (qPCR) is a well-established method for quantifying levels of gene expression, but has not been routinely applied to the detection of constitutional copy number alterations of human genomic DNA.

Transgenerational effects in both plants and animals are often associated with alterations in methylation of genomic DNA [1], [2], [22].

Such changes may include, but are not limited to: gene expression modulation, epigenetic alterations, and loss of genomic stability in both the epithelial and stromal compartments.