Sentence examples for alterations of established from inspiring English sources

Many basal-like breast cancer patient samples display alterations of established drivers of cancer development, including elevated expression of EGFR, p53 inactivating mutations and loss of expression of the tumor suppressor PTEN; however, their contribution to human basal-like breast cancer pathogenesis remains ill-defined.

Sudden alterations of established reward contingencies in the environment are a disturbance to any system.

A range of X-ray doses was used and large alterations in latent period for growth to 2 mm diameter were followed by smaller alterations in the growth rate of established tumours.

Their results reveal an unexpected alteration of the chromatin state of established MeCP2 target genes in lymphocytes of human subjects with RTT.

Our results reveal an unexpected alteration of the chromatin state of established MeCP2 target genes in lymphocytes of human subjects with RTT.

This change may imply a climatically driven alteration of the established fire-regime promoted by fuel accumulation that portends major ecological consequences.

Most importantly, these antibody results indicate that F. hepatica initially stimulated a Th2-biased response in our co-infection experiments and, thus, the classical activation state of macrophages and Th1-biased cytokine profiles we observed in co-infected mice reflect an alteration of the established F. hepatica-induced Th2-biased response by T. gondii.

Hepatic morphologic alterations and features of portal hypertension identify most cases of established cirrhosis.

We observed fluoxetine-induced alterations in expression of several cytokines indicative of glial activation, and observed that fluoxetine enhanced glial activation in the vicinity of established brain metastases.

The present study extends these observations to include alterations in effector and memory phenotypes associated with LF, alterations (once established) that remain despite clearance of infection.

One example of this is the quantitative characterization of alterations in defined, established metabolic pathways from complex metabolomic data.