Sentence examples for alterations of distinct from inspiring English sources

The investigation on gene signatures and alterations of distinct cell subpopulation in heterogeneous pools of adult NSCs in relation to aging may bring a new strategy for revealing novel mechanisms for stem cell aging.

Furthermore, alterations of distinct metabolic pathways were detected which offer novel insights into the switch of individual metabolite pattern along with the decline in insulin sensitivity.

Overall, G × E was abundant and frequently large in magnitude, presenting a pattern in which different genetic backgrounds responded to fluctuations in copper exposure through alterations of distinct transcriptional programs.

In human, the quality of bone cancer pain is marked by substantial heterogeneity, either due to the cancer or resulting from the alteration of distinct bone structures.

Moreover, our specific characterization of peripheral alterations to distinct subsets of immune cells may provide biomarkers for diagnosing and characterizing the degree of TBI severity, progression and/or recovery.

Under this scenario, it can be postulated that recognition of fungal elicitors would trigger alterations in the expression of distinct miRNAs which are responsible of reprogramming host developmental processes, including auxin-regulated processes.

30 A number of distinct alterations have been identified including point mutations within the nucleotide-binding loop in exon 18, small deletions in exon 19 or insertions in exon 20, as well as point mutations in the activation loop in exon 21.

The third molecular subtype of lower-grade gliomas had wild-type IDH and displayed a range of genetic alterations completely distinct from those of IDH-mutant lower-grade gliomas (Fig.  1).

Stem/progenitor cell aging involves not only alterations in the molecular characteristics of distinct subtypes of NSC/NPCs, but also changes in the cellular microenvironment, including blood supplies, content of cerebrospinal fluid, and interplays amongst not only NSC/NPCs but also surrounding cells.

This finding is in agreement with previous reports and supports the suggestion of distinct genetic alterations and pathways in SI-NETs [ 15, 16].

However, it is not known to what extent these tissue studies reflect alterations in gene-expression profiles of distinct mammary epithelial cell subpopulations.