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Because the reproductive system does not fully mature until late puberty, this time in development is a window of susceptibility to chemicals that affect the endocrine system, potentially resulting in alterations of development or later reproductive health (Golub et al. 2008).
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Chromosome 17 was most heavily affected by secondary genomic alterations on development of TKI resistance during disease progression [32], [33].
By further increasing the doses, more severe alterations of vascular development were observed with both morpholinos.
"While both dietary groups developed plaque when exposed to polluted air, the high-fat diet led to more consistent and statistically significant increase alterations of plaque development.
Structural alterations of skeletal development may also be related to local trauma arising from laryngoscopy or tracheal intubation, which is more common in premature infants [ 8, 21, 22].
Alterations of CB development have also been associated with respiratory dysfunction in neonates and children (for recent reviews see Perez & Keens, 2013; Porzionato et al, 2013; Gozal et al, 2013).
In conclusion, our large prospective study was the first study to look at early alterations in haemostasis following breast cancer chemotherapy, and the first to screen for VTE and relate such alterations to development of VTE.
The alteration of cortical development in our cohort is consistent with perturbed prenatal brain development.
Classical homocystinuria is an autosomal recessive disorder caused by cystathionine β-synthase (CBS) deficiency and characterized by distinctive alterations of bone growth and skeletal development.
Neuroanatomical studies and the associations with teratogens strongly suggest that the mechanism includes alteration of brain development soon after conception.
Neuroanatomical studies and the associations with teratogens strongly suggest that autism's mechanism includes alteration of brain development soon after conception.
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CEO of Professional Science Editing for Scientists @ prosciediting.com