The phrase "alterations necessary to" is correct and usable in written English.
It can be used when discussing changes or modifications that need to be made to something in order to achieve a desired outcome.
Example: "The alterations necessary to improve the design were implemented after the feedback from the focus group."
Alternatives: "changes required to" or "modifications needed to".
1952 Act July 16 , 1952 made railroads share equally with proprietors of highways in bearing cost of alterations necessary to remove obstacles to navigation.
Another way of improving LSBs scheme is to reduce the amount of alterations necessary to be introduced into the cover image for data hiding when the number of secret bits is significantly less than that of available cover pixels.
We are currently dissecting the minimal set of genetic alterations necessary to switch on the ability to acquire drug resistance, and dissecting the drug resistance signatures by microarray analysis.
From a cellular viewpoint, the processes related to the water deficit response begin with stress perception, followed by signal transduction, and a change in gene expression that finally confers the complex metabolic and physiological alterations necessary to gain stress tolerance [ 11, 12].
Thus, CBX2 overexpression might represent an alteration necessary to mediate the downstream epigenetic effect of PRC2 gain of function.
However, a deeper understanding of the functional consequences of these alterations is necessary to guide appropriate therapeutic strategies.
A mouse model of human HCC with inducible expression of MYC in adult liver cells has shown that overexpression of MYC is sufficient to initiate HCC development; however, these tumors develop with a prolonged latency, suggesting that other genetic alterations are necessary to generate HCC, including mutations in the p53 pathway [32], [37], [38], [39], [40].
These results may imply that at least six genetic alterations are necessary to convert a normal cell into a fully malignant cancer cell in SCLC.
Alternatively, the TGF-β1 treatment times were not long enough to induce EMT, the small sample size used may not be representative, or the cells may not have the genetic alterations necessary for TGF-β1 to induce EMT.
Thus the ccB signature may reflect the transcriptomic impact of these poor prognosis alterations, but more than one alteration may be necessary to establish this phenotype, and as yet unknown alterations are also likely to contribute.
Recycled Dreams has an on-staff seamstress to make any alterations necessary.
