In the earliest stages, the principal endothelial alteration is merely functional and addressed as "endothelial dysfunction".
This further implies that the skipping event is associated with the degree of exon alteration not merely a random outcome of genome editing approach.
First, we evaluated whether the effects on perception of the back (and force applied to it) were specific to the type of sound used – if so, this would provide compelling evidence that perceptual alterations were not merely due to the use of sound alone.
This indicates that selective pressures operate during the expansion of tumour-associated stromal cells and that alterations do not merely reflect genetic drift.
Thus, for our purposes, changes in tumor glucose uptake caused merely by alterations in blood glucose were not true treatment effects but fall into our definition of false positive results.
Owing to hundreds of alterations that might be merely consequential to transformation, the use of in vitro model of human cells expressing known oncogenes was proposed as a useful approach to focus on the pathogenic changes displayed by tumors.
According to this concept, glycemia per se regulates hepatic glucose output whereas acute alterations of gluconeogenesis lead merely to mirror changes in glycogenolysis [ 40].
Given that AEA, PEA, and OEA are all substrates for FAAH, the opposing impact of OA/RA on levels of these compounds suggests that these changes are not due merely to alterations in FAAH-mediated metabolism and argues against an important contribution of the entourage effect.
There is now substantial evidence not merely that alterations in the subchondral bone metabolism are secondary manifestations of OA, but that they comprise an integral component of the disease, and data suggest a key role played by the subchondral bone in the initiation and/or progression of articular tissue degeneration.
The alteration sometimes could be merely a reduction in islet size nβ, but more often more profound changes to the islet cytoarchitecture occur.
