In addition, to altered gene regulation patterns in cancerous conditions, it is reported that alterations may exist in the carbohydrate structures attached to the protein backbone or in the protein backbone itself.
Interestingly, scintigraphic evidence of metabolic myocardial alterations may exist even in the absence of clinical features of cardiac disease, possibly representing a subclinical type of neurogenic stunned myocardium.
This demonstrates that SMAD4 is not preferentially mutated in the breast, though rare genetic alterations may exist in the MH2 coding region.
The multifocal nature of prostate cancer, whereby different genetic alterations may exist in different tumor foci of a prostate, however, increases the likelihood of missing a high-grade focus.
A reduction in the ADAM23-mediated LGI1-stimulation of neurite outgrowth in the central nervous system was suggested to contribute to epilepsy, although other yet unknown ADAM-LGI-mediated alterations may exist [ 23].
