Sentence examples for alterations led to from inspiring English sources

These results suggest that p43-induced mitochondrial alterations led to a general reduction in MyHC expression, particularly MyHC-IIx.

Furthermore, such alterations led to dramatic changes in the transcript levels of genes involved in the response to stress, as well as in DNA repair [22].

These alterations led to a profound defect in the ability of TIL to produce IFN-γ in response to TCR stimulation.

As shown in Fig. 6A, most of the alterations led to frame-shift or nonsense mutations in the gene, which is likely to abolish the function of the domain and cause stabilization of the mutant proteins.

These results demonstrate that, while both the Δ7 and ΔY cytoplasmic tail alterations led to impaired MHC-I endocytosis in DCs, point mutation of the single conserved tyrosine residue resulted in a much more pronounced internalization defect compared to complete deletion of the 13 amino acids comprising exon 7.

Both these nutritional alterations led to further behavioral changes to a subsocial insect.

We hypothesized that arsenic alters gene expression in the lung and that the alterations lead to carcinogenesis by direct and indirect means.

It will take more research to determine which precise alterations lead to autism or other neurological problems, they say.

These surface property alterations lead to negligible cell adhesion through minimal matrix protein adsorption and also modified surface modulus.

These alterations lead to secretion of inflammatory cytokines and neuronal dysfunction [22], and seem to be a common feature to all neuroinflammatory syndromes [23].

Further research is needed in this area to better understand the complex biologic pathways involved in normal growth and to determine which molecular alterations lead to increased degrees of asymmetry in patients.