The phrase "alterations is very" is not correct in written English due to subject-verb agreement issues.
It can be used in a context where "alterations" is the subject, but it should be followed by a plural verb, such as "are."
Example: "The alterations are very noticeable in the final design."
Alternatives: "changes are quite" or "modifications are very."
Moreover, seeing all three alterations is very rare in IDHmut gliomas, only occurring in 4 % regardless of grade.
Since the list of candidate genes involved in these alterations is very large and has been discussed elsewhere [ 19- 21], we will not elaborate in a detailed discussion of individual candidates.
It is intriguing that three tumours (#23 25) showed alterations of both IGF2/ H19 and KIP2/ Limprintedntedomainsns, because each domain is independently regulated, and BWS with both alterations is very rare (DeBaun et al, 2002).
AKT/PI3K/mTOR pathway alterations are very frequent in bladder cancer, with 73% of human bladder tumours characterised by alterations in one of the major pathway components: TSC1, PI3K (PIK3CA) or PTEN [29].
The essential steps in TMC generation described here are basically in agreement with results of other authors working in MSC transformation [7] [11], [32] and these alterations are very similar to molecular changes associated with transformation of other cell types.
These results suggest that microsatellite alterations are very uncommon in acute myeloid leukaemia.
Some of those alterations are very likely relevant to the carcinogenic process.
Phonation alterations are very common in children with AOB (77.8 %), and distortion is the most frequent type of dyslalia (75.8 %).
Only 8% of centenarians had a normal ECG; thus, the frequency of ECG alterations was very high.
– Epigenetic alterations are very common in BWS and include hypermethylation of ICR1 (5–10%) and/or hypomethylation of ICR2 (50 60%).
Even though DNA alterations are very common among these aCGH arrays, LAD-aFL can still identify both weak as well as stronger DNA alterations.
