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Whether these changes in muscle cells are causative of ALS or a consequence of motor neuron alterations is not yet clear, but their elucidation is very important, since the understanding of the mechanisms involved in mutant SOD1 toxicity in muscle may facilitate the design of treatments directed toward this specific tissue to treat ALS or at least to delay disease progression.
More recent evidence suggested that the effect of cytokine levels' alterations is not a singular effect, that is, cytokines that promote inflammation can also have anti-inflammatory and immunosuppressive actions [34].
The consequence the nature of N-glycan alterations is not completely understood yet.
27 However, the clinical relevance of these bone alterations is not yet clear.
A comprehensive detection of these alterations is not an inaccessible summit.
The functional significance for these sequence alterations is not clear yet (Ganesan et al. 2009).
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Dr. Asefi's alterations were not always subtle.
But these types of genetic alterations are not inherited.
Alterations are not denigrated as corrections of mistakes.
However, ECG alterations are not independently related to outcome.
Collectively, specific mutations or DNA copy number alterations are not predictive of response to ACT.
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