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Thus, the spectrum of alterations is likely to reflect a composite of selection and particular failures in genome surveillance mechanism(s).
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As these two genomic alterations are likely to alter the function of the protein and were not found in the control population, it is likely that they are pathogenic mutations, but functional studies will be necessary to determine how each of these MSH6 mutations affects protein function.
A decision is likely to be reached after Thursday's individual time trial, and any alterations are likely to have a major effect on whether Nibali's race leadership can be challenged.
Cumulative impacts of human alterations are likely to exert the most pronounced influence on fire behavior during periods of drought and under conditions of extreme fire weather.
The observed alterations are likely immunophenotypic correlates of the pathophysiological processes underlying nitrovasodilator-induced migraine attacks and indicate that signalling via CGRP receptors but not sGC-mediated mechanisms may be enhanced through endogenous NO production.
"Our analysis suggests that ecstasy-induced serotonergic alterations are likely to be overestimated for the majority of users.
Alterations are likely to affect the pacemaker mechanism itself [40].
These abnormal chlamydial developmental forms characterized by their ultra-structural morphological alterations are likely aberrant bacteria observed in persistent infections [14], [45].
However, the fact that Ccl8 and Apod were not expressed in the peripheral leukocyte populations isolated from young and old C57BL/6 mice, suggests that these alterations are likely to be intrinsic to the smooth muscle cells and fibroblasts.
We have neglected disadvantageous alterations since in large tumors, cells carrying such alterations are likely unable to establish a surviving clone, but go extinct due to their deleterious characteristics.
The consequences of the structural alterations are likely reflected in functional deficits found in the hippocampus in response to respiratory and autonomic challenges, and in psychological and autonomic impairments accompanying the syndrome.
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