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However, the precise molecular mechanism leading to these alterations is currently unknown although epigenetic modifications of gene expression by fetal exposure to phytoestrogens are a plausible hypothesis.
The identification of genomic alterations is currently transforming our understanding of the genetic basis of leukemogenesis.
The basis for this intriguing relationship between site/cell of origin and certain molecular alterations is currently unclear.
Overall, the work by Ji et al. [ 3] has relevant implications, as the occurrence of reprogramming-mediated genomic alterations is currently a major obstacle hindering the use of iPSCs in medical applications [ 21].
The use of effluent biomarkers as an early sign of peritoneal membrane alterations is currently under debate [ 27– 29] specially because clinical factors cannot give an accurate individual prediction for EPS [ 30].
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Molecular targeted therapies against similar genetic alterations are currently available for other malignancies, but their efficacy in urothelial carcinoma has not been established.
In addition, correlations between changed expression levels of genes and their corresponding genomic alterations are currently investigated [ 15, 16].
These defined alterations are currently evaluated for their use as biomarkers for diagnosis, prognosis and prediction of therapy response for different cancers [101].
New animal models reproducing these late alterations are currently being developed, and such models will help us to answer the burning question – should we treat endocrine alterations in critically ill patients?
In this regard, 'Indicators of Hydrologic Alteration' is currently considered one of the most effective approaches for assessing hydrologic alteration (HA).
In spite of this importance, the etiology including genetic alteration is currently unrevealed.
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