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The reciprocal relationship between KRAS mutation and copy number alterations is also observed in gastric cancer [ 11].
Oxidative stress leading to mitochondrial DNA alterations is also documented in patients with myoclonic epilepsy [ 137, 138].
A prospective clinical trial assessing the efficacy of ponatinib (a multi-kinase FGFR inhibitor) on advanced SqCC with FGFR kinase alterations is also underway (NCT01761747).
Furthermore, monitoring and evaluation of all of the executive stages of the project to introduce necessary alterations is also quite vital and necessary.
Despite of the initiating role in FTC, the coexistence of PI3K/Akt pathway-related genetic alterations is also found to play a role in facilitating progression and dedifferentiation in thyroid cancer [ 5, 7, 8].
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Histopathological alterations were also studied.
Methylation alterations were also seen in regions of their DNA associated with growth and development.
Other genetic alterations are also frequently found in these tumors.
The clinical implications of these genetic alterations were also analyzed.
Meanwhile, substantial alterations were also observed in metabolites related to oxidative stress.
Tissue alterations were also evaluated semi-quantitatively by the degree of tissue change.
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