Sentence examples for alterations indicating from inspiring English sources

Thirty percent of tumors had multiple targetable alterations, indicating opportunities for combination therapy.

Microarray analysis by Blenkiron et al. showed that miR-33a expression is often lost in human primary breast cancers because of chromosome alterations, indicating that miR-33a may function as a tumor suppressor (Blenkiron et al., 2007).

Knockout of single HDAC family members in mice produces a variety of phenotypes ranging from early embryonic death to viable animals with only discrete alterations, indicating that potential side effects of HDAC inhibitors depend on the selectivity of the compounds.

The disruption of either axis prevents cerebral microvascular alterations, indicating that the two signaling pathways are non-redundant.

We also demonstrated that chronic administration of polyphenols from green tea can have a similar, although less efficient than normalizing the gene copy number, corrective effect on brain alterations indicating that the diet is bringing the level of active DYRK1A to a value between the values produced in the transgenic and the wild type situations.

Spectra showing profile alterations indicating deoxyhemoglobin reabsorption were discarded.

The early onset of genetic alterations indicated that they might be the tumor initiating steps in the development of cancer.

These alterations indicate loss of functionality, intense destruction of liver parenchyma and disorganization of portal spaces, as a result of intense toxicity.

These alterations indicate that the R1Y variant is an imperfect mimic of the native WT1 peptide, and suggest caution in its use as a therapeutic vaccine.

Their alterations indicated that autophagy participated lipid metabolism to generate energy and form autophagosomes with significantly increased free fatty acids and glycerophospholipids, which protected wild-type MEFs from serious damages and delayed cell death.

Non-clonal chromosomal alterations (NCCAs) such as defective mitotic figures, chromosomal fragmentation, missegregation or non-recurrent genomic alterations indicate a dynamic process leading to instability [39].