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Thus, different alterations in turnover of mRNA and protein levels at either steady state or non-steady state conditions could display as divergent changes in cross-sectional evaluations on tissue samples.
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Changes in the rate of bone turnover are an important determinant of bone disease because alterations in bone turnover rate have been associated with an increased fracture risk.
Type 1 diabetes mellitus (T1DM) and estrogen deficiency are associated with several alterations in bone turnover.
However, alterations in the turnover of pulmonary cells are less well understood.
Patients with chronic kidney disease (CKD) develop renal osteodystrophy with alterations in bone turnover, mineralization, and volume (TMV).
Some potential factors implicated in the functional decline of muscle include programmed cell death, oxidative stress, alterations in protein turnover, inflammation, hormonal dysregulation, disuse, and mitochondrial dysfunction[5] [10].
This could indicate alterations in bone turnover.
There were no significant alterations in bone turnover markers during testosterone treatment (Kenny et al 2001).
Using this approach, we did not detect alterations in protein turnover of IRF1 upon BV6 treatment (Supplementary Figure 15B).
From this part of the bone, secondary osteons were marginalized to periosteum suggesting alterations in bone turnover.
Changes in hormone concentrations may lead to significant alterations in protein turnover due to high metabolism in response to differences in photoperiod.
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